Acetaminophen has competitive effects on the inhibition of catecholamines by the adrenergic beta receptor site. Pharmacological effect is similar to propranolol, but weaker. Long-lasting effect, T1 / 2 is 3-8 hours. By weakening or preventing receptor excitement, the contractile force and contraction speed of the heart are reduced, and the conduction speed of the conduction system is slowed, so that the heart's response to exercise or stress is weakened. Therefore, it is used in the treatment of angina pectoris to reduce myocardial oxygen consumption and increase exercise tolerance. Adrenaline is used to treat cardiac arrhythmias because it blocks excitatory adrenaline. It is possible that this product lowers blood pressure through central, adrenergic neuron block, antirenin activity, and reduced cardiac output, and is suitable for treating hypertension. Because this product can antagonize the catecholamine effect, it is also used to treat pheochromocytoma and hyperthyroidism, so that the activities of 1 and 2 receptors are in an inhibited state.
Acetaminophen has competitive effects on the inhibition of catecholamines by the adrenergic beta receptor site. Pharmacological effect is similar to propranolol, but weaker. Long-lasting effect, T1 / 2 is 3-8 hours. By weakening or preventing receptor excitement, the contractile force and contraction speed of the heart are reduced, and the conduction speed of the conduction system is slowed, so that the heart's response to exercise or stress is weakened. Therefore, it is used in the treatment of angina pectoris to reduce myocardial oxygen consumption and increase exercise tolerance. Adrenaline is used to treat cardiac arrhythmias because it blocks excitatory adrenaline. It is possible that this product lowers blood pressure through central, adrenergic neuron block, antirenin activity, and reduced cardiac output, and is suitable for treating hypertension. Because this product can antagonize the catecholamine effect, it is also used to treat pheochromocytoma and hyperthyroidism, so that the activities of 1 and 2 receptors are in an inhibited state.
- Name
- Acebutolol
- Name
- Acebutolol
- Chinese alias
- Acetobutanol
- English alias
- Acecor, Monitan, Neptal
- CAS
- 37517-30-9
Acetaminophen Basic Information
Name:
Chinese alias: acetobutanoic acid; N- [3-acetyl-4- (2-hydroxy-3-isopropylaminopropoxy) phenyl] butanamide;
Name: acebutolol
English alias: N- (3-Acetyl-4- (2-hydroxy-3- (isopropylamino) propoxy) phenyl) butyramide; Acebutolol; Acebutolol, (±)-;
CAS number: 37517-30-9
Molecular formula: C 18 H 28 N 2 O 4
Molecular weight: 336.42600
Exact mass: 336.20500
PSA: 87.66000
LogP: 2.82940
The physical and chemical properties of acebutolol
Appearance and properties: crystal
Density: 1.118g / cm 3
Melting point: 119-123ºC
Boiling point: 564.1ºC at 760 mmHg
Flash point: 295ºC
Refractive index: 1.542
Storage conditions: storeroom ventilated, low temperature and dry
Instruction for acebutrolol
The name of fenbutrolol classification
Primary Category: Circulatory Drugs Secondary Category: Antihypertensive Drugs Third Category: Beta Receptor Blockers
Acetaminophen drug Name
Acebutolol
Acetaminophen drug alias
Butyroyl, Acecor, Monitan, Neptal
Acebutalol drug dosage form
1. Tablet: 400mg; 2. Capsule: 200mg; 3. Injection: 25mg.
Pharmacological effects of acebutolol
This product is a long-acting 1 receptor blocker. Its action intensity is 1/5 to 1/10 of propranolol. The sympathomimetic activity is 2 to 3 times the dose of -blocker. It slows down the resting heart rate than propranolol. Medicine Quan. Online www.med126.com The drug has a weaker myocardial inhibitory effect than propranolol, and its effect on peripheral vascular resistance is not obvious. A moderately lipophilic drug, acebutolol has no significant effect on normal human metabolism.
Acetonolol pharmacokinetics
Intestinal absorption, peak plasma concentration in 2 to 4 hours. 84% bound to plasma proteins. The half-life in plasma is 3-6 hours. Its metabolite diacetalol has selective -receptor blockade and its elimination half-life in plasma is more than 12 hours.
Acebutrolol indication
For hypertension and arrhythmia.
Contraindications of acebutrolol
See also Propranolol
Precautions
Acebutolol See also: propranolol
Acebutrolol adverse reactions
Adverse reactions are minor, but the cardiac function is obviously impaired, and those with high atrioventricular block should not be used.
Acebutolol dosage
Oral: Start with 400 mg each time, once a day; if necessary, increase to 400 mg each time, twice a day.
Acebutolol drug interactions
See also Propranolol
Expert review
See propranolol.
