Meloxicam is an enol nonsteroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. The selective inhibition of cyclooxygenase-2 (COX-2) has a weak inhibitory effect on cyclooxygenase-1, so there are fewer adverse reactions such as the digestive system.
Basic Information
- Name
- Meloxicam
- Name
- Meloxicam
- Pinyin
- Meiluoxikang
- Molecular formula
- C14H13N3O4S2
- Molecular weight
- 351.40
- Character
- Light yellow or yellow powder
- Indication
- Symptoms of rheumatoid arthritis
- Store
- Sealed and sealed
Meloxicam Indication
It is suitable for the symptomatic treatment of rheumatoid arthritis and osteoarthritis, such as pain, swelling and inflammation of soft tissues, traumatic pain and pain after surgery.
Meloxicam clinical application
Oral
Osteoarthritis is 7.5mg a day, and it is taken once, and the maximum daily dose is 15mg;
Ankylosing spondylitis and rheumatoid arthritis 15mg a day, divided into two doses, can also be reduced to 7.5mg a day. The maximum daily dose is 15 mg for adults and 7.5 mg for seniors.
2. Rectal administration
Osteoarthritis 7.5 15mg, stuffed into the anus before going to bed;
Ankylosing spondylitis and rheumatoid arthritis 15mg or 7.5mg, stuffed into the anus before going to bed. 7.5mg for the elderly, stuffed into the anus before going to bed.
3. Other
Not recommended for children under 15 years.
Meloxicam adverse reactions
Including gastrointestinal reactions (common indigestion, nausea, abdominal pain or diarrhea; rare ulcers, bleeding or perforation); anemia, leukopenia or thrombocytopenia, itching, rash; stomatitis; slight dizziness, headache; edema, elevated blood pressure, etc. Elevated liver enzymes were common (10%), and occasional renal damage (0.4%). Most of them disappeared after discontinuation.
Meloxicam precautions
Patients with renal failure on dialysis should not exceed 7.5 mg / day. Use with caution in patients who have a history of gastrointestinal disease and are currently using anticoagulants.
Meloxicam contraindications
The following conditions are prohibited: patients with asthma, nasal polyps, angioedema or urticaria after using aspirin or other non-steroidal anti-inflammatory drugs; patients with active peptic ulcer, severe liver dysfunction, and severe renal function in non-dialysis patients Patients with insufficiency; patients with gastrointestinal bleeding, cerebral hemorrhage or other bleeding disorders; patients with severe uncontrolled heart failure; children and adolescents younger than 15 years, pregnant or breastfeeding.
Meloxicam drug interactions
1. Combined with methotrexate to increase the blood toxicity of methotrexate.
2. Combination of oral anticoagulants and thrombolytic agents may increase bleeding.
3. It can reduce the antihypertensive and diuretic effects of -adrenoceptor blockers, angiotensin-converting enzyme inhibitors, diuretics (except furosemide), and thiazide drugs.
4. Combined with potassium-preserving diuretics to reduce diuretic effects, which may cause hyperkalemia or toxic kidney damage.
5. Combined with cyclosporine, the risk of cyclosporine poisoning increases.
6. Combined with levofloxacin and ofloxacin, the risk of seizures increases.
Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.
