Nadolol, also known as naphthol and SQ-11725, has a chemical formula of benazepine and is a white or almost white crystalline powder chemical with a molecular formula of C
17 H
27 NO
4 and a molecular weight of 309.40100, slightly soluble in water, easily soluble in ethanol, almost insoluble in acetone. Nadolol is a cardiovascular drug that is mainly used in the treatment of hypertension, angina pectoris, arrhythmia, hyperthyroidism, migraine and so on.
Nadolol, also known as naphthol and SQ-11725, has a chemical formula of benazepine and is a white or almost white crystalline powder chemical with a molecular formula of C 17 H 27 NO 4 and a molecular weight of 309.40100, slightly soluble in water, easily soluble in ethanol, almost insoluble in acetone. Nadolol is a cardiovascular drug that is mainly used in the treatment of hypertension, angina pectoris, arrhythmia, hyperthyroidism, migraine and so on.
- Name
- Nadorol
- Name
- Nadolol
- CAS number
- 42200-33-9
- Molecular formula
- C17H27NO4
- Molecular weight
- 309.40100
Introduction to Nadorol
Nadorol Basic Information
Name: benzbutazone
Chinese alias: Hydronaphthalene
Name: (2 R , 3 S ) -5- [3- (tert-butylamino) -2-hydroxypropoxy] -1,2,3,4-tetrahydronaphthalene-2,3-diol
English alias: Nadololum [INN-Latin]; nadolol; [14C] -Nadolol; Solgol; 5- [3- (tert-butylamino) -2-oxopropoxy] -1,2,3,4-tetrahydronaphthalene-2,3- diol;
CAS number: 42200-33-9
Molecular formula: C 17 H 27 NO 4
Chemical structure:
Molecular weight: 309.40100
Exact mass: 309.19400
PSA: 81.95000
LogP: 1.02570
Nadolol physical and chemical properties
Appearance and properties: white solid
Density: 1.189g / cm 3
Melting point: 125-130ºC
Boiling point: 526.4ºC at 760mmHg
Flash point: 272.2ºC
Refractive index: 1.573
Storage conditions: Refrigerator
Nadorol Safety Information
Customs code: 2922509090
Overview of Nadorol drug-related information
Nadorol Role and Use
The effect of this product is similar to Putalol, but 2-4 times. Mainly showing weakened myocardial contractility, slowed heart rate, reduced cardiac output, decreased blood pressure and decreased plasma renin activity. Partially absorbed after oral administration, the bioavailability is about 30% ; peak blood concentration is reached after 3-4 hours. In plasma, the binding rate to plasma proteins is 30%, and there is no liver first-pass effect. t ½ is 14-24 hours. V d is 2L / kg. About 70% are excreted from the kidneys in the original form, and the rest are excreted by feces .
Nadorol usage and dosage
Oral, 40mg / time at the beginning, once a day; later, the dose can be gradually increased to 80-320mg / day depending on the effect .
Nadorol notes
Adverse reactions and contraindications were similar to propranolol. should be used with caution in patients with impaired renal function.
Nadorolol preparations and specifications
Commonly used tablets, each 40mg: 80mg; 120mg .
