Hydrocodone, also known as dihydrocodeinone, is a chemical with white to pale yellow crystals. The molecular formula is C18H21NO3, the molecular weight is 299.36400, and the melting point is 198 ° C. Hydrocodone is an antipyretic and analgesic. It is mainly used clinically for cough and relieves moderate to severe pain caused by various reasons. Currently available varieties: paracetamol hydrocodone, 5mg hydrocodone bitartrate and 500mg paracetamol.
Hydrocodone, also known as dihydrocodeinone, is a chemical with white to pale yellow crystals. The molecular formula is C18H21NO3, the molecular weight is 299.36400, and the melting point is 198 ° C. Hydrocodone is an antipyretic and analgesic. It is mainly used clinically for cough and relieves moderate to severe pain caused by various reasons. Currently available varieties: paracetamol hydrocodone, 5mg hydrocodone bitartrate and 500mg paracetamol.
- Name
- Hydrocodone
- Name
- Hydrocodone
- CAS number
- 125-29-1
- Molecular formula
- C18H21NO3
Hydrocodone compounds
Hydrocodone Basic Information
Name: dihydrocodeinone
Name: hydrocodone
English alias: Bekadid; (4R, 4aR, 7aR, 12bS) -9-methoxy-3-methyl-1,2,4,4a, 5,6,7a, 13-octahydro-4,12-methanobenzofuro [3,2 -e] isoquinoline-7-one; hidrocodona; 7,8-dihydrocodeinone; Dicodid;
CAS number: 125-29-1
Molecular formula: C 18 H 21 NO 3
Chemical structure:
Molecular weight: 299.36400
Exact mass: 299.15200
PSA: 38.77000
LogP: 1.87120
Hydrocodone physicochemical properties
Appearance and properties: white to light yellow crystal
Density: 1.31 g / cm3
Melting point: 198ºC
Boiling point: 461.4ºC at 760 mmHg
Flash point: 232.9ºC
Refractive index: 1.633
Vapor pressure: 1.07E-08mmHg at 25 ° C
Hydrocodone Basic Information
[ Common name ] Hydrocodone
[ Name ] hydrocodone
[ Introduction ] Hydrocodone is a semi-synthetic anesthetic, analgesic and antitussive drug. It has a variety of activities similar to the codeine properties. Most of these effects are related to the central nervous system and smooth muscle. In other words, it is an anesthetic that can be used to relieve pain.
Available varieties: Paracetamol hydrocodone tablets, 5mg hydrocodone bitartrate and 500mg paracetamol.
Hydrocodone usage and dosage
Oral administration
Antitussive, moderate to severe pain
Adult: Hydrocodone tartrate: 5-10 mg every 4-6 hours.
Hydrocodone pharmacological action
Hydrocodone is a phenanthrene derivative and is an opioid analgesic. A commonly used formulation is hydrocodone tartrate, which is mainly used to relieve irritating cough. The drug is often used in combination with acetaminophen to relieve moderate to severe pain.
Metabolism: May be metabolized in the liver.
Excretion: Most are excreted through urine. Healthy adult half-life: 3.8 hours.
Hydrocodone pharmacokinetics
Five adult men took 10 mg of hydrocodone orally. The average peak plasma concentration was 23.6 ± 5.2 ng / ml, the peak time was 1.3 ± 0.3 h, and the plasma t 1/2 was 3.8 ± 0.3 h. Hydrocodone exhibits complex metabolic patterns including O-demethyl, N-demethyl and 6-ketone reduction to 6- and 6- hydroxyl metabolites .
Hydrocodone precautions
Head trauma, acute alcoholism, convulsive disease, elevated intracranial pressure, elderly, weak, hypothyroidism, adrenal insufficiency, asthma, kidney or liver damage, enlarged prostate, hypotension, shock, inflammation or obstruction Intestinal disease, myasthenia gravis, drug dependent patients, children <1 year old, pregnant women who are breastfeeding should use with caution. Affects the ability to drive and operate machinery .
Hydrocodone adverse reactions
Nausea, vomiting, constipation, drowsiness, confusion, central nervous system abnormalities, cardiovascular disease, dry mouth, sweating, flushing, decreased libido, narrowed pupils, convulsions.
Serious adverse reactions: respiratory depression .
FDA Hydrocodone FDA pregnancy classification
Animal studies have proven that the drug is harmful to the fetus (teratogenic or embryonic death, etc.), or there have not been controlled pregnant women, or pregnant women and animals. This class of drugs should only be used after weighing the benefits to the pregnant woman over the harm to the fetus.
Hydrocodone drug interactions
1. Drinking alcohol while taking hydrocodone tartrate tablets can enhance central inhibition.
2. The use of hydrocodone tartrate tablets in patients receiving monoamine oxidase inhibitor therapy can enhance central inhibition.
3. Combined with sedative hypnotics and tricyclic antidepressants can enhance its sedative, analgesic and respiratory depression effects.
4. Combined with its anesthetic, it can aggravate central inhibitory effect.
5. Enhanced effects when combined with other central nervous system inhibitors .
