Inflammatory vascular response and leukocyte response are achieved through a series of chemical factors. The chemical factors involved in and mediating the inflammatory response are called chemical mediators or inflammatory mediators. The mechanisms of vasodilation, increased permeability, and leukocyte exudation in acute inflammatory reactions are important topics in the mechanism of inflammation. Some inflammatory factors can directly damage the endothelium and cause increased vascular permeability, but many inflammatory factors do not directly affect local tissues, but mainly cause inflammation through the action of endogenous chemical factors, so they are also called Chemical or inflammatory mediator.
Inflammatory mediator
Inflammatory vascular response and leukocyte response are achieved through a series of chemical factors. The chemical factors involved in and mediating the inflammatory response are called chemical mediators or inflammatory mediators. The mechanisms of vasodilation, increased permeability, and leukocyte exudation in acute inflammatory reactions are important topics in the mechanism of inflammation. Some inflammatory factors can directly damage the endothelium and cause increased vascular permeability, but many inflammatory factors do not directly affect local tissues, but mainly cause inflammation through the action of endogenous chemical factors, so they are also called Chemical or inflammatory mediator.
- Name
- Inflammatory mediator
- Name
- inflammatory mediator
- Concept
- Vasodilation in acute inflammatory response
- Positioning
- Important Issues in the Mechanism of Inflammation
Inflammatory vascular response and leukocyte response are achieved through a series of chemical factors. Chemical factors that participate in and mediate the inflammatory response are called chemical or inflammatory mediators.
Vasoactive amine
Includes histamine and serotonin (5-HT). Histamine is mainly found in
Inflammatory mediators produced in body fluids There are three interrelated systems in plasma, namely kallikrein, complement and the coagulation system; important inflammatory mediators.
Features | Types of inflammatory mediators |
Vasodilation | Histamine, Bradykinin, PGE2, PGD2, PGF2, PGI2, NO |
Increased vascular permeability | Histamine, bradykinin, C3a, C5a, LTC4, LTD4, LTE4 PAF, reactive oxygen metabolites, substance P, platelet activating factor |
Chemotaxis | C5a, LTB4, bacterial products, neutrophil cationic proteins, cytokines (eg IL-8) |
heat | Cytokines (IL-1, IL-6, and TNF, etc.), PG |
pain | PGE2, bradykinin, substance P |
Tissue damage | Oxygen free radical, lysosomal enzyme, NO |
Note: the name can refer to the previous
There are two points worth noting about the role of inflammatory mediators.
Different media systems are closely related to each other
The activation of complement, kallikrein, the coagulation system and the fibrinolytic system is closely related to its products, and the effects of these inflammatory mediators are also intertwined.
Almost all media are in a sensitive regulation and balance system
On the one hand, the medium that is tightly isolated in the cell or the precursor that is in the plasma and tissue must undergo many steps to be activated. During its transformation, the rate-limiting mechanism controls the biochemical response of the medium speed. On the other hand, once the medium is activated and released, it will be quickly inactivated or destroyed. It is through this regulatory system that the body makes the media in a dynamic equilibrium.
